Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

15 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Adipocytokines and E-cadherin in colorectal carcinomas

ABSTRACT: Expression of adipocytokines and glucocorticoid related genes are associated with down regulation of E-cadherin mRNA in colorectal carcinomas

ORGANISM(S): Homo sapiens

DISEASE(S): adenocaricinoma

SUBMITTER: Torben Luders

PROVIDER: E-MTAB-833 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

mRNA expression of adipocytokines and glucocorticoid-related genes are associated with downregulation of E-cadherin mRNA in colorectal adenocarcinomas.

Størkson Ragnhild H RH Aamodt Rolf R Vetvik Katja Kannisto KK Pietilainen Kirsi K Bukholm Geir G Jonsdottir Kristin K Vollan Hilde S HS Sonerud Tonje T Lüders Torben T Jacobsen Morten B MB Bukholm Ida R K IR

International journal of colorectal disease 20120314 8

<h4>Background</h4>There is a consistently reported relationship between the incidence of colon cancer and obesity. It is thought that adipose tissue, particularly visceral fat, which secretes systemic factors that alter immunological, metabolic and endocrine milieu and promotes insulin resistance by producing adipocytokines, is important in cancer progression. Systemic high concentrations of adipocytokines, such as tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and glucocorticoi ...[more]

PMID: 22411584

Similar Datasets

Transcription profiling by array of human breast tumors and adjacent cancer-free tissue to study Bmi-1 and Mel-18 expression

Project description:A total of 79 breast tumors (71 malignant tumors, 6 fibroadenomas, and 2 DCIS) were studied and compared to the reduction mammoplastic specimens of 12 healthy women as well as adjacent cancer-free tissue for 23 of the malignant tumors. Polycomb Group (PcG) proteins Bmi-1 and Mel-18 were then studied more closely first on mRNA expression level using microarray data from two of our ongoing projects and then on protein expression level using immunohistochemistry.

2010-07-01 | E-MTAB-271 | biostudies-arrayexpress

mRNA profiling of pre- and postoperative breast tumors

Project description:Gene expression studies on breast cancer have generally been performed on tissue obtained at the time of surgery. Overexpression of several genes may be a result of surgical trauma or preoperative manipulation, and may not reflect any biological impact of the disease. This study compares the expression profiles in preoperative tissue while tumor is still in its normal milieu to postoperative tissue from the same tumor obtained during surgery.

2011-03-01 | E-MTAB-470 | biostudies-arrayexpress

Gene Expression Profile Analysis of T1 and T2 Breast Cancer Tumors

Project description:The purpose of this study is to search for molecular signatures characterizing clinical T1 and T2 tumors and to better identify patients of high risk of relapse and/or metastasis. In total 46 samples, 29 T1 and 17 T2 infiltrating ductal carcinomas, were included.

2013-01-17 | E-MTAB-1049 | biostudies-arrayexpress

miRNA profiling of pre- and postoperative breast tumors

2011-03-01 | E-MTAB-469 | biostudies-arrayexpress

miRNA in benign tumors

Project description:miRNA expression profiles from benign breast tumors, breast cancers, and normal breast tissue

2011-03-01 | E-MTAB-471 | biostudies-arrayexpress

Micro-RNA expression signatures in breast cancer progression

Project description:miRNA expression in breast cancer progression, from normal breast tissue to DCIS to subtype-specific invasive breast carcinomas. Two separate datasets are used, of which this is one. The other is also publicly available. These samples are collected at Akershus Univeristy Hospital, Norway, as part of a consecutive series and total RNA is extracted from snap-frozen biopsies.

2016-04-30 | E-MTAB-3759 | biostudies-arrayexpress

SCREENING STUDY TO IDENTIFY DIAGNOSTIC MARKERS FOR LUNG CANCER IN ENDOBRONCHIAL LINING FLUID

Project description:We investigated whether biomarker analysis in endobronchial epithelial lining fluid (ELF) collected by bronchoscopic microsampling may be useful for a definitive preoperative diagnosis. Therefore we compared ELF samples close to nodule and from the contralateral site from patients with malignant or benign diagnosis. ELF samples have been derived from early stage NSCLC patients and controls. LIMMA analysis was performed to identify differentially expressed genes associated to a malignant diagnosis. keywords: disease subtype analysis

2011-12-31 | E-GEOD-27489 | biostudies-arrayexpress

Global Mapping of Histone H3 K4 and K27 Trimethylation: Lineage Fate Determination of Differentiating CD4+ T Cells

Project description:Multipotential naïve CD4+ T cells differentiate into distinct lineages including Th1, Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4+ T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications or plasticity in T cell responses. We generated genome-wide histone H3 lysine 4 (H3K4) and lysine 27 (H3K27) trimethylation maps in naïve, Th1, Th2, Th17, iTreg, and natural (n)Treg cells. We find that while modifications of signature cytokine genes (Ifng, Il4, and Il17) partially conform to the expectation of lineage commitment, critical transcription factors such as Tbx21 exhibit a broad spectrum of epigenetic states, consistent with our demonstration of T-bet and IFN-γ induction in nTreg cells. Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4+ T helper cell differentiation. genome-wide analysis of histone H3 K4 and K27 trimethylation in different sub-lineages of mouse CD4+ T cells. (12 samples in total)

2009-01-21 | E-GEOD-14254 | biostudies-arrayexpress

Transcription profiling of human hMADS cells during adipocyte and osteoblast differentiation

Project description:human adipocyte and osteoblast differentiation of hMADS cells

2008-08-08 | E-MARS-10 | biostudies-arrayexpress

Dynamic miRNA Expression Patterns During Retina Regeneration in Zebrafish: Loss of Dicer Inhibits Regeneration

Project description:Background: Adult zebrafish spontaneously regenerate their retinas after damage. Although a number of genes and signaling pathways involved in regeneration have been identified, the extent of mechanisms regulating regeneration is unclear. Small non-coding RNAs, microRNAs (miRNAs), that regulate regeneration of various tissues in lower vertebrates were examined for their potential roles in regulating zebrafish retinal regeneration. Results: To investigate the requirement of miRNAs during zebrafish retinal regeneration, we knocked down the expression of the miRNA-processing enzyme Dicer in retinas prior to light-induced damage. Dicer loss significantly reduced proliferation of Müller glia-derived neuronal progenitor cells during regeneration. To identify individual miRNAs with roles in retina regeneration, we collected retinas at different stages of light damage and performed small RNA high-throughput sequencing. We identified subsets of miRNAs that were differentially expressed during active regeneration but returned to basal levels once regeneration was completed. To validate the roles of differentially expressed miRNAs, we knocked down 6 different miRNAs that were upregulated in expression during regeneration and demonstrated that they have distinct effects on neuronal progenitor cell proliferation and migration during retina regeneration. Conclusions: miRNAs are necessary for retinal regeneration. miRNA expression is dynamic during regeneration. miRNAs function during initiation and progression of retinal regeneration. Identification of miRNAs before, during and after completion of zebrafish retinal regeneration

2014-09-20 | E-GEOD-58702 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data