Transcriptional profiling by array of human head and neck squamous cell carcinoma to study the correlation between galectin-1 upregulation and the presence of SMA positive cancer-associated fibroblasts

ABSTRACT: In this study, we set the presence of smooth muscle actin (SMA)-positive cancer-associated fibroblasts (CAFs) in relation to galectin-1 and its in vivo competitor (galectin-3). In squamous cell carcinomas of head and neck, upregulation of galectin-1 presence is highly significantly correlated to presence of smooth muscle actin-positive cancer-associated fibroblasts in the tumor. In order to pinpoint correlations on the molecular level, we applied microarray analyses to the transcription profiles of the corresponding tumors. Significant correlations of several transcripts were detected with the protein level of galectin-1 in the cancer-associated fibroblasts.

ORGANISM(S): Homo sapiens

DISEASE(S): tumour

SUBMITTER: Michal Kolar 

PROVIDER: E-MTAB-850 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress