Single-cell RNA-sequencing of mouse thymic epithelial cells across the first year of life

ABSTRACT: The thymus shapes the T cell receptor repertoire, and is one of the first organs to rapidly age, with gross changes in cellularity and architecture. To resolve the nature of these changes we used SMART-Seq2 on FACS purified thymic epithelial cells (TEC) across the first year of mouse life. We sorted 4 TEC populations in each of 5 mice at each age (1 week, 4 weeks, 16 weeks, 32 weeks and 52 weeks old).

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Jeanette Baran-Gale 

PROVIDER: E-MTAB-8560 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress