Agilent Microarray of formalin-fixed, paraffin-embedded mesenteric adipose tissue associated with different amount of fibrosis from ileocolonic resection specimens of Crohn’s disease patients

ABSTRACT: In Crohn’s disease (CD) pathology, we observed that: 1) a continuous process of fibrosis includes all the layers of the intestine as well as the surrounding mesenteric adipose tissue (MAT); 2) the amount of fibrosis in the MAT varies between samples even within a single case. To further investigate the molecular features of this fibrosis pattern, we did a paired study using formalin-fixed, paraffin-embedded blocks from ileocolonic resection specimens of seven CD patients. Specifically, one block contained ≥10% fibrosis amount while the other block contained <10% fibrosis amount within the MAT from the same case. MAT was selectively collected from serial histologic sections and total RNA was extracted for the Agilent Microarray analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Shanshan Xiong 

PROVIDER: E-MTAB-8570 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress