Effects of increased intracellular calcium and overnutrition on pancreatic beta cell transcriptome

ABSTRACT: To determine the individual and combined effects of excitotoxicity and overnutrition on beta-cell gene expression, we analyzed the impact of a high fat diet (HFD) on wild type C57Bl/6J and Abcc8 knockout mice of different sexes. We collected 31 bulk RNA-Seq datasets that originated from FACS-purified pancreatic beta-cells that differed by genotype, diet, and sex.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Mark Magnuson 

PROVIDER: E-MTAB-8643 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress