Dataset Information
Transcription profiling by array of embryonal carcinoma cell line P19 with or without expressoin of Blimp1-EGFP fusion protein over a 48-hour time-course to study the role of Blimp1 in transcription regulation in pluripotent embryonic cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Erna Magnúsdóttir
PROVIDER: E-MTAB-865 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A tripartite transcription factor network regulates primordial germ cell specification in mice.
Nature cell biology 20130714 8
Transitions in cell states are controlled by combinatorial actions of transcription factors. BLIMP1, the key regulator of primordial germ cell (PGC) specification, apparently acts together with PRDM14 and AP2γ. To investigate their individual and combinatorial functions, we first sought an in vitro system for transcriptional readouts and chromatin immunoprecipitation sequencing analysis. We then integrated this data with information from single-cell transcriptome analysis of normal and mutant PG ...[more]
