22 PDX of triple-negative breast cancer genotyped with Affymetrix Cytoscan HD

ABSTRACT: To characterize Homologous recombination deficiency (BRCAness) in triple-negative breast cancer PDX models genomic signature was utilized. After normalization using ChAS we obtained absolute copy number profiles using the GAP software (Popova et al, Genome Biol, 2009). The number of Large-scale State Transitions (LSTs) was used to annotate PDX as BRCAness or not (Popova et al, Cancer Res 2012).

ORGANISM(S): Homo sapiens

SUBMITTER: Elisabetta Marangoni 

PROVIDER: E-MTAB-8653 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress