Post-exposure effect of whole cigarette smoke on in vitro 3D human airway epithelial tissues from large and small epithelial cells

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a disease state characterized by poorly reversible, limited airflow that is usually both progressive and associated with an abnormal inflammatory response of the lung. One cause of COPD is chronic exposure to airborne materials such as cigarette smoke (CS), which leads to impaired respiratory function in damaged tissues. Damaged epithelial tissue initiates repair processes including proliferation and re-differentiation until there is complete regeneration of a pseudostratified epithelium. These repair processes in airway epithelial tissues are essential for maintaining normal airway function. However, impairment of epithelial repair leads to architectural changes through region-dependent remodeling processes that are associated with a fixed a

ORGANISM(S): Homo sapiens

SUBMITTER: Shigeaki Ito 

PROVIDER: E-MTAB-8680 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress