Molecular characterization of T-cell lymphoblastic lymphoma in children and adolescents (SNParrays)

ABSTRACT: T-cell lymphoblastic lymphoma (T-LBL) is a heterogeneous malignancy of lymphoblasts committed to T-cell lineage. Dismal outcomes (15-30%) in case of T-LBL relapses warrants for risk-based treatment to be established in future. This is a first comprehensive, systematic, integrated genome-wide analysis including relapse cases aimed towards identifying molecular markers of prognostic relevance for T-LBL. Whole exome sequencing (WES) was performed on “limited cohort” of 16 T-LBL cases which included 6 relapse cases. Validation of WES data was performed on a large cohort (n=131) referred as \"extended cohort\". In order to identify copy number alterations and determine the epigenetic changes SNP arrays and methylation arrays were also performed respectively on the \"limited cohort\". Activated

ORGANISM(S): Homo sapiens

SUBMITTER: Christian Wünsch 

PROVIDER: E-MTAB-8763 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress