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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene Expression profile of Breast Cancer Stem Cell-like HMLE_sh_ECad cells after treatment with DMSO or CID49843203

ABSTRACT: Breast Cancer stem cell-like line, HMLEshECad, and isogenic control line, HMLEshGFP, were treated with DMSO or with Breast Cancer Stem Cell-like Cell selective compound CID49843203

ORGANISM(S): Homo sapiens

SUBMITTER: Carmody Leigh

PROVIDER: E-MTAB-884 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells.

Carmody Leigh C LC Germain Andrew R AR VerPlank Lynn L Nag Partha P PP Muñoz Benito B Perez Jose R JR Palmer Michelle A J MA

Journal of biomolecular screening 20120830 9

Cancer stem cells (CSCs) are resistant to standard cancer treatments and are likely responsible for cancer recurrence, but few therapies target this subpopulation. Due to the difficulty in propagating CSCs outside of the tumor environment, previous work identified CSC-like cells by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad). A phenotypic screen was conducted against HMLE_sh_ECad with 300 718 compounds from the Molecular Libra ...[more]

PMID: 22941295

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