Single-cell RNA-seq of tumor-infiltrating lymphocytes in metastatic uveal melanoma

ABSTRACT: Metastatic uveal melanoma generally responds poorly to immunotherapy. The aim here was to sequence tumor-infiltrating lymphocytes from uveal melanoma metastases to study their phenotypes and T-cell receptor (TCR) clonotypes. We performed paired single-cell transcriptome and TCR sequencing using the 10x Genomics platform of IL2-expanded tumor-infiltrating lymphocytes from 7 liver and 1 subcutaneous metastasis.

INSTRUMENT(S): Illumina MiSeq, NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Joakim Karlsson 

PROVIDER: E-MTAB-8846 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress