Dataset Information
Single-cell RNA-seq of the human fetal lateral ganglionic eminence at 7, 9 and 11 post-conceptional weeks
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Homo sapiens
SUBMITTER: Giulio Pavesi
PROVIDER: E-MTAB-8894 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The coding and long noncoding single-cell atlas of the developing human fetal striatum.
Science (New York, N.Y.) 20210501 6542
Deciphering how the human striatum develops is necessary for understanding the diseases that affect this region. To decode the transcriptional modules that regulate this structure during development, we compiled a catalog of 1116 long intergenic noncoding RNAs (lincRNAs) identified de novo and then profiled 96,789 single cells from the early human fetal striatum. We found that D1 and D2 medium spiny neurons (D1- and D2-MSNs) arise from a common progenitor and that lineage commitment is establish ...[more]
