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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Identical transcriptome reprograming by interferon lambda 3 and 4 and its absence in IFNLR1 or IL10R2 deficient cells rules out the IFNL4 non-canonical signaling hypothesis

ABSTRACT: Lambda interferons IFNL1-3 mediate antiviral immunity by inducing interferon sensitive genes (ISGs) in epithelial tissues. Contrarily, a variant creating the functional gene IFNL4 is associated with impaired clearance of hepatitis C virus (HCV) despite of higher liver expression of ISGs in untreated HCV patients. We aimed to explore IFNL4 signaling mechanism by comparing expression profiles from human hepatic cell line clones with genetic modifications influencing the ISG signaling pathway (IFNLR1/IL10R2 knockouts, IFNL4/IFNL3 expression stimulation by transfection).

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Jan Kubovčiak

PROVIDER: E-MTAB-8916 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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