Effect of miR-106b~25 in mouse spermatogenesis and male fertility

ABSTRACT: We investigated the miRNA cluster miR-106b~25 as potential candidate causing male infertility. We analized single and double KO mice. Single KO show derregulation of multiple molecular pathways and disrupted early spermatogenesys, but retain fertility. Double KO show severely disrupted testicular histology and significantly reduced fertility.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus

SUBMITTER: Miguel Burgos 

PROVIDER: E-MTAB-8964 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress