Transcription profiling of mouse IFNg-primed C57BL/6 and C3H.BL6-sst1 bone-marrow macrophages infected with mycobacterium tuberculosis
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Igor Kramnik
PROVIDER: E-MTAB-90 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
An improved empirical bayes approach to estimating differential gene expression in microarray time-course data: BETR (Bayesian Estimation of Temporal Regulation).
Aryee Martin J MJ Gutiérrez-Pabello José A JA Kramnik Igor I Maiti Tapabrata T Quackenbush John J
BMC bioinformatics 20091210
<h4>Background</h4>Microarray gene expression time-course experiments provide the opportunity to observe the evolution of transcriptional programs that cells use to respond to internal and external stimuli. Most commonly used methods for identifying differentially expressed genes treat each time point as independent and ignore important correlations, including those within samples and between sampling times. Therefore they do not make full use of the information intrinsic to the data, leading to ...[more]
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