Transforming growth factor β (TGFβ) and BMP7 regulate glioblastoma stem cells differentiation status

ABSTRACT: Glioblastoma stem cells (GSCs) fate is controlled by environmental cues, among which cytokines play a crucial role. The transforming growth factor β (TGFβ) family signaling pathways controls GSCs. On one hand, TGFβ promotes cell proliferation in GBM, it induces the expression of platelet-derived growth factor-B (PDGFB). Moreover, TGFβ, via its signaling mediators Smad2/3, induces the expression of the cytokine leukemia inhibitory factor (LIF) and Sox4, which in turn enhances the expression of the stem cell transcription factor Sox2; this increases the self-renewal capacity of the GSCs and their stemness characteristics, and enhances the GSC tumor-initiating potential. On the other hand, Bone morphogenic proteins (BMPs) are known to promote GSC differentiation towards the astrocytic phenoty

ORGANISM(S): Homo sapiens

SUBMITTER: Laia Caja Puigsubirà 

PROVIDER: E-MTAB-9076 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress