RNA-seq of small intestinal organoids treated with an inhibitor for the epigenetic modifier LSD1

ABSTRACT: To assess the role of LSD1 in mice small intestinal epithelium, small intestinal organoids were treated with an inhibitor for LSD1 (GSK-LSD1) and compared to untreated organoids. Similar to intestinal epithelium from mice with an intestinal epithelium specific LSD1-KO, paneth cells dissappear upon GSK-LSD1 treatment. We used these sequencing data to show that these small intestinal organoids have a similar phenotype as mice epithelium without LSD1.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Mus musculus

SUBMITTER: Håvard Lindholm 

PROVIDER: E-MTAB-9077 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress