Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Gene expression in lung cells expressing MycER/KrasG12D from a transgenic mouse model of non-small cell lung cancer


ABSTRACT: A transgenic mouse model of Kras-driven lung adenocarcinoma, with reversible activation of Myc, was used to explore the effect of Myc activity on lipid metabolism in lung tumours. Gene expression analysis links lipid metabolism, transport and storage to Myc activity. Lung cells from adeno-cre infected R26LSL-CMER and LSL-KrasG12D; R26LSL-CMER mice were isolated 14 days post-treatment with (LSL-KrasG12D; R26LSL-CMER and R26LSL-CMER) or without (R26LSL-CMER only) tamoxifen. GFP positive cells were FACs sorted. To increase RNA yield, cells from two mice of the same genotype and treatment were combined. There were two biological replicates for each condition. Gene expression was compared between lung cells with inactive MycER and lung cells expressing active MycER plus or minus KRasG12D.

ORGANISM(S): Mus musculus

SUBMITTER: Zoe Hall 

PROVIDER: E-MTAB-9131 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2022-03-05 | GSE128138 | GEO
2022-06-08 | E-MTAB-10807 | biostudies-arrayexpress
2011-09-14 | E-GEOD-27717 | biostudies-arrayexpress
2019-06-30 | GSE132096 | GEO
2011-09-15 | GSE27717 | GEO
2011-09-15 | GSE27675 | GEO
2011-09-14 | E-GEOD-27675 | biostudies-arrayexpress
2021-02-20 | GSE167073 | GEO
2011-01-28 | E-GEOD-26850 | biostudies-arrayexpress
2022-08-30 | E-MTAB-11122 | biostudies-arrayexpress