Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents

ABSTRACT: We aimed to identify blood gene expression patterns associated to psychopathological trajectories retrieved from a large community, focusing on the emergence and remission of general psychiatric symptoms. Hundred and three individuals from the Brazilian High-Risk Cohort Study (BHRCS) for mental disorders were classified in four groups according to Child Behavior Checklist (CBCL) total score at the baseline (w0) and after 3 years (w1): low–high (L–H) (N = 27), high–low (H–L) (N = 12), high–high (H–H) (N = 34) and low–low (L–L) groups (N = 30). Blood gene expression profile was measured using Illumina HT-12 Beadchips, and paired analyses comparing w0 and w1 were performed for each group.

ORGANISM(S): Homo sapiens

SUBMITTER: Marcos Santoro 

PROVIDER: E-MTAB-9200 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress