RNA-seq of human prostate cancer cell line with IRF7 knock-down treated with radiation against wild-type control

ABSTRACT: Abstract/Project overview Tumour recurrence can be influenced by the mutational status of a tumour but also how the tumour responds to therapy. Whilst activation of Type 1 interferon signalling is a hallmark of how cells respond to viral infection, in cancer cells, multiple stresses are known to activate this same response. In this study we have evaluated for the first time the changes in the interferon response induced by culturing prostate cancer cells under sphere-forming conditions and following irradiation. We identify that both stresses induced a selection/reprogramming towards a tumour-initiating/stem-like cell population That are known to be highly adaptable and have been shown to be resistant to multiple therapies. We report a conserved upregulated transcript profile for both c

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Kelsey McCulloch 

PROVIDER: E-MTAB-9286 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress