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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of human ovarian cancer cell line SKOV3 treated with BMP2 against untreated controls

ABSTRACT: To elucidate the biological function of BMP2 in ovarian cancer cells, SKOV3, a human ovarian cancer cell line, was stimulated with BMP2.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Tomohiko Fukuda

PROVIDER: E-MTAB-9479 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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BMP signaling is a therapeutic target in ovarian cancer.

Fukuda Tomohiko T Fukuda Risa R Tanabe Ryo R Koinuma Daizo D Koyama Hiroo H Hashizume Yoshinobu Y Moustakas Aristidis A Miyazono Kohei K Heldin Carl-Henrik CH

Cell death discovery 20201205 1

BMP signaling has been found to have tumor-promoting as well as tumor-suppressing effects in different types of tumors. In this study, we investigated the effects of BMP signaling and of BMP inhibitors on ovarian cancer (OC) cells in vitro and in vivo. High expression of BMP receptor 2 (BMPR2) correlated with poor overall survival of OC patients in the TCGA dataset. Both BMP2 and BMPR2 enhanced OC cell proliferation, whereas BMP receptor kinase inhibitors inhibited OC cell growth in cell culture ...[more]

PMID: 33298901

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