Pulmonary fibroblastic stromal cells maintain metabolic fitness of protective inflationary memory CD8+ T cells - T cell data

ABSTRACT: Inducing the long-term protection via effector memory CD8+ T cells residing in the peripheral tissues is the ultimate goal of T cell-based vaccination strategies. CD8+ T cell reacting against a particular set of antigenic peptides show propensity to generate stable pools of memory inflating cells with profound protective capacity. While the epitopes that induce memory inflation have been thoroughly characterized and used as excellent constituents of vaccines such as recombinant adenoviruses, the identity of the tissue factors responsible for maintaining memory inflating CD8+ T cells remains elusive. Here, we have used a Cre recombinase-dependent, -galactosidase (gal)–recombinant adenovirus vector that allowed for cell-specific expression of gal epitopes and identification of cell types

INSTRUMENT(S): Illumina NovaSeq 6000, NextSeq 500

ORGANISM(S): Mus musculus

SUBMITTER: Mechthild Lütge 

PROVIDER: E-MTAB-9580 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress