Mir profiling of human whole blood samples from kidney transplant recipients from BIOMARGIN consortium

ABSTRACT: We investigated blood miRNAs as potential non-invasive biomarkers in kidney transplantation as part of the BIOMARGIN consortium (ClinicalTrials.gov, number NCT02832661). Blood samples were collected at time of the 717 renal allograft biopsies, in four European transplant centers. Profiling of mIR transcriptomes was performed in a multistage discovery-to-validation study. Antibody-mediated rejection (ABMR) is the most common cause of allograft failure after kidney transplantation. The revised Banff 2017 classification defines ABMR as conditions in which histologic evidence of acute and chronic injury is associated with evidence of current/recent antibody interaction with vascular endothelium and serologic evidence of donor-specific antibodies (DSA) to human leukocyte antigen (HLA) or non-H

ORGANISM(S): Homo sapiens

SUBMITTER: Nicolas Cagnard 

PROVIDER: E-MTAB-9595 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress