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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice

ABSTRACT: Acute Pten loss initiates prostate tumorigenesis characterized by cellular senescence response. Senescent cells secrete a variety of pro inflammatory factors in the tumor microenvironment, which can support the survival, outgrowth and migration of tumor cells. Here we examine cytokines and cytokines-related factors gene expression in Ptenpc-/- senescent and in Ptenpc-/-; Trp53pc-/- non senescent tumors. RNAseq analysis confirmed the presence of cytokines, which were specifically up- and down-regulated in Ptenpc-/- senescent tumors (“core-SASP”) we also found a number of upregulated secreted factors that were “senescence-unrelated” both present in both Ptenpc-/- and Ptenpc-/-; Trp53pc-/- tumors.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Mus musculus

SUBMITTER: Martina Troiani

PROVIDER: E-MTAB-9624 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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