Modulation of microRNA-194 and Cell Migration by HER2-targeting Trastuzumab in Breast Cancer

ABSTRACT: We found that trastuzumab (herceptin) treatment significantly decreased five miRNAs and increased three others in SKBr3 cells, whereas in BT474 cells it significantly decreased two miRNAs and increased nine. The only miRNA that shared the same change in both cell lines was miRNA-194 (miR-194), which was upregulated following trastuzumab treatment.

ORGANISM(S): Homo sapiens

SUBMITTER: George Calin 

PROVIDER: E-MTAB-965 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress