Changes in Pdgfra-positive mesenchymal progenitors during muscle regeneration under normal and obese condition.

ABSTRACT: Worldwide increases in obese and elderly populations synergistically enhance the incidence of sarcopenia. Accumulation of intermuscular adipose tissue (IMAT) is considered to be a major problem whereby obesity leads to sarcopenic obesity and thus is a promising target for treating this emerging pathological condition. However, while sarcopenic obesity-associated IMAT is suggested to be originated from PDGFRα+ mesenchymal progenitors, processes of their adipogenesis remain largely unexplored. Here we investigated intracellular changes associated with these processes using scRNA-Seq analysis.

INSTRUMENT(S): DNBSEQ-G400

ORGANISM(S): Mus musculus

SUBMITTER: Masaki Takasugi 

PROVIDER: E-MTAB-9715 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress