Dataset Information
Affymetrix expression arrays from hippocampus of Ms2Yah mouse model of Down syndrome
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Damien MARECHAL
PROVIDER: E-MTAB-988 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndrome.
Genetics 20140421 3
Down syndrome (DS) is due to increased copy number of human chromosome 21. The contribution of different genetic regions has been tested using mouse models. As shown previously, the Abcg1-U2af1 genetic region contributes to cognitive defects in working and short-term recognition memory in Down syndrome mouse models. Here we analyzed the impact of monosomy of the same genetic interval, using a new mouse model, named Ms2Yah. We used several cognitive paradigms and did not detect defects in the obj ...[more]
