Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2500
ORGANISM(S): Homo sapiens
SUBMITTER: Carlos Martinez-Perez
PROVIDER: E-MTAB-9917 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Xia Youli Y He Xiaping X Renshaw Lorna L Martinez-Perez Carlos C Kay Charlene C Gray Mark M Meehan James J Parker Joel S JS Perou Charles M CM Carey Lisa A LA Dixon J Michael JM Turnbull Arran A
Clinical cancer research : an official journal of the American Association for Cancer Research 20220801 16
<h4>Purpose</h4>Endocrine therapy resistance (ETR) remains the greatest challenge in treating patients with hormone receptor-positive breast cancer. We set out to identify molecular mechanisms underlying ETR through in-depth genomic analysis of breast tumors.<h4>Experimental design</h4>We collected pre-treatment and sequential on-treatment tumor samples from 35 patients with estrogen receptor-positive breast cancer treated with neoadjuvant then adjuvant endocrine therapy; 3 had intrinsic resista ...[more]