Dataset Information
Transcription profiling of intestine, kidney and liver tissues from adult male knock-out mice for all Cyp3a genes versus wild type mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Cor Lieftink
PROVIDER: E-NCMF-1 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.
The Journal of clinical investigation 20071101 11
Cytochrome P450 3A (CYP3A) enzymes constitute an important detoxification system that contributes to primary metabolism of more than half of all prescribed medications. To investigate the physiological and pharmacological roles of CYP3A, we generated Cyp3a-knockout (Cyp3a-/-) mice lacking all functional Cyp3a genes. Cyp3a-/- mice were viable, fertile, and without marked physiological abnormalities. However, these mice exhibited severely impaired detoxification capacity when exposed to the chemot ...[more]
