Dataset Information
Transcription profiling of Brca1- and p53-deficient mouse mammary tumors to treatment with doxorubicin, docetaxel or cisplatin
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Cor Lieftink
PROVIDER: E-NCMF-5 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 20070711 29
We have studied in vivo responses of "spontaneous" Brca1- and p53-deficient mammary tumors arising in conditional mouse mutants to treatment with doxorubicin, docetaxel, or cisplatin. Like human tumors, the response of individual mouse tumors varies, but eventually they all become resistant to the maximum tolerable dose of doxorubicin or docetaxel. The tumors also respond well to cisplatin but do not become resistant, even after multiple treatments in which tumors appear to regrow from a small f ...[more]
