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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human dermal endothelial cells treated with 10ng/ml VEGF and 20ng/ml basic Fibroblast Growth Factor (bFGF) for 6h

ABSTRACT: Cells were treated with 10ng/ml VEGF and 20ng/ml basic Fibroblast Growth Factor (bFGF) for 6h at 37°C with 5 % CO2 and 95 % humidity..

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Wagner

PROVIDER: E-RZPD-14 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional network governing the angiogenic switch in human pancreatic cancer.

Abdollahi Amir A Schwager Christian C Kleeff Jörg J Esposito Irene I Domhan Sophie S Peschke Peter P Hauser Kai K Hahnfeldt Philip P Hlatky Lynn L Debus Jürgen J Peters Jeffrey M JM Friess Helmut H Folkman Judah J Huber Peter E PE

Proceedings of the National Academy of Sciences of the United States of America 20070724 31

A shift of the angiogenic balance to the proangiogenic state, termed the "angiogenic switch," is a hallmark of cancer progression. Here we devise a strategy for identifying genetic participants of the angiogenic switch based on inverse regulation of genes in human endothelial cells in response to key endogenous pro- and antiangiogenic proteins. This approach reveals a global network pattern for vascular homeostasis connecting known angiogenesis-related genes with previously unknown signaling com ...[more]

PMID: 17652168

Similar Datasets

Transcription profiling of human dermal endothelial cells treated with 20ng/ml basic Fibroblast Growth Factor (bFGF) for 6h

Project description:Cells were treated with 20ng/ml basic Fibroblast Growth Factor (bFGF) for 6h at 37°C with 5 % CO2 and 95 % humidity.

2007-04-25 | E-RZPD-16 | biostudies-arrayexpress

Transcription profiling of human dermal endothelial cells treated with 10ng/ml VEGF for 6h

Project description:Cells were treated with 10ng/ml VEGF for 6h at 37°C with 5 % CO2 and 95 % humidity..

2007-04-25 | E-RZPD-15 | biostudies-arrayexpress

Transcription profiling of human dermal endothelial cells treated with 10ng/ml VEGF and 20ng/ml basic Fibroblast Growth Factor (bFGF) for 6h

Project description: Not available

| S-ECPF-RZPD-14 | biostudies-other

Transcription profiling of human dermal endothelial cells treated with 200ng/ml human recombinant endostatin for 6h

Project description:Cells were treated with 200ng/ml human recombinant endostatin (Pichia Pastoris) for 6h at 37C with 5 % CO2 and 95 % humidity.

2007-04-25 | E-RZPD-20 | biostudies-arrayexpress

Evaluation and comparison of the glyco-gene expression profile of endothelial cells stimulated with VEGF, bFGF and galectin-3

Project description:Dr. Panjwani's laboratory is focusing on the mechanism by which galectins-3 and 7 mediate corneal epithelial cell migration. Recently published studies, that we have confirmed and expended on in our laboratory, clearly demonstrate that galectin-3 mediates angiogenesis in vitro and in vivo. More interestingly we have found that bFGF- and VEGF-mediated angiogenesis can be inhibited by galectin-3 inhibitors, which suggests an important role of carbohydrate recognition systems in the process of angiogenesis. In an effort to characterize the role of carbohydrate recognition system in angiogenesis, we are interested to evaluate and compare the glyco-gene expression profile of endothelial cells stimulated with VEGF, bFGF and galectin-3 at time and concentration at which, the compounds stimulate angiogenesis in vitro.

2011-04-29 | GSE28943 | GEO

Evaluation and comparison of the glyco-gene expression profile of endothelial cells stimulated with VEGF, bFGF and galectin-3

2011-04-29 | E-GEOD-28943 | biostudies-arrayexpress

Picocystis sp. ML strain:ML

Project description:Picocystis sp. ML strain:ML Genome sequencing and assembly

| PRJNA490491 | ENA

Transcription profiling of human dermal enothelial cells treated with 200ng/ml human recombinant endostatin (Pichia Pastoris)

Project description:Cells were treated with 200ng/ml human recombinant endostatin (Pichia Pastoris) for 6h at 37°C with 5 % CO2 and 95 % humidity.

2013-01-30 | E-RZPD-10 | biostudies-arrayexpress

Transcriptome analysis of bFGF and WNT3A treated stem cells isolated from human exfoliated deciduous teeth

Project description:bFGF regulated stemness maintenance and cell differentiation in stem cells isolated from human exfoliated deciduous teeth (SHEDs). In addition, WNT3A is also shown to regulate osteogenic differentiation in mesenchymal stem cells. Here, transcriptome analysis of bFGF and WNT3A treated SHEDs was evaluated using a high throughput RNA sequencing technique. Results demonstrated that bFGF regulated genes related to cell cycle control and cell proliferation in SHEDs.

2020-07-07 | GSE131758 | GEO

The role of BFGF-related transcriptional regulation in calcification model of valve interstitial cells induced by osteoblastic medium

Project description:Purpose:To explore the the function and underlying mechanisms of basic fibroblast growth factor (BFGF) on calcific aortic valve disease (CAVD) a. Methods: The valvular interstitial cells were isolated from porcine aortic valve leaflets. To investigate the effect of BFGF on osteogenic differentiation of VICs, the osteogenic induced medium (OIM) and BFGF were added. RNA sequencing is used to identify changes in gene proffles. Results:This analysis completed the full transcriptome sequencing of 9 samples, with a total of 2 differentially expressed gene groups. The number of differentially expressed genes detected was 2526, 159. 6596 lncRNAs were identified, and the number of differentially expressed lncRNAs detected was 349,100. 6179 new circRNAs were predicted, and the number of differentially expressed circRNAs detected was 4,243. Conclusions:This study completed for the first time to the sequencing of the full transcriptome expression of valve interstitial cells under the action of BFGF, and has proved that BFGF can inhibit the calcification process of valve interstitial cells, our study suggests that bFGF has important value in the prevention and treatment of CAVD.

2023-05-01 | GSE225698 | GEO

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