Transcription profiling of germ-free transgenic mice colonized with genotyped Helicobacter pylori strains from a case-control study of gastric cancer

ABSTRACT: Helicobacter pylori infects the stomachs of half of all humans. It has a relatively benign relationship with most hosts, but produces severe pathology, including gastric cancer, in others. Identifying the relative contributions of host, microbial and environmental factors to the outcome of infection has been challenging. Here, we describe one approach for identifying microbial genes that affect the magnitude of host responses to infection. Single colony purified H. pylori isolates were obtained from 25 cases and 71 controls in a Swedish case-control study of gastric cancer. Strains were first phenotyped based on their ability to produce adhesins that recognize two classes of human gastric epithelial receptors. Thirteen binding strains and two non-binding controls were then subjected to who

ORGANISM(S): Helicobacter pylori

SUBMITTER: Nina Salama 

PROVIDER: E-SMDB-1581 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress