Transcription profiling of diffuse large B-cell lymphoma identifying different subtypes

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history reflects unrecognized molecular heterogeneity in the tumours. Using DNA microarrays, we have conducted a systematic characterization of gene expression in B-cell malignancies. Here we show that there is diversity in gene expression among the tumours of DLBCL patients, apparently reflecting the variation in tumour proliferation rate, host response and differentiation state of the tumour. We identified two molecularly distinct forms of DLBCL which had gene expression patterns indicative of different st

ORGANISM(S): Homo sapiens

SUBMITTER: Ash Alizadeh 

PROVIDER: E-SMDB-183 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress