Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of human serum stimulation fibroblasts controls

ABSTRACT:

ORGANISM(S): Homo sapiens

SUBMITTER: Vishy Iyer

PROVIDER: E-SMDB-20 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Serum stimulation of fibroblasts controls

Project description:The transcriptional program in the response of human fibroblasts to serum control group. This study is described more fully in Iyer VR, et al. 1999. Science 283:83-7 Keywords: other

2002-06-27 | GSE57 | GEO

Serum stimulation of fibroblasts

Project description:The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered in groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated. This study is described more fully in Iyer VR, et al. 1999. Science 283:83-7 Keywords: other

2002-06-27 | GSE58 | GEO

Expression data for serum stimulation of human primary fibroblasts

Project description:We used microarrays to profile gene expression changes following growth factor stimulation of primary human fibroblasts.

2010-05-01 | GSE20641 | GEO

Serum stimulation of fibroblasts with cycloheximide

Project description:The transcriptional program in the response of human fibroblasts to serum. Serum was added to fibroblasts in the presence of cycloheximide. This study is described more fully in Iyer VR, et al. 1999. Science 283:83-7 Keywords: time-course

2002-06-27 | GSE56 | GEO

Serum stimulation of fibroblasts experiment set

Project description:The transcriptional program in the response of human fibroblasts to serum. Serum was added to fibroblasts, and samples were taken. This study is described more fully in Iyer VR, et al. 1999. Science 283:83-7 Keywords: time-course

2002-06-27 | GSE55 | GEO

Transcription profiling of human foreskin fibroblasts CRL 2091 (ATCC) serum starved for 48 hours, Serum Stimulation time series

Project description:Foreskin fibroblasts CRL 2091 (ATCC) were serum starved for 48 hours, and harvested at the indicated time points after switching to media with 10% FBS essentially as described (Iyer et al., 1999). RNA from all of the sampled time points were pooled as reference RNA to compare with RNA from individual time points as described (Iyer et al., 1999).

2005-10-31 | E-SMDB-2503 | biostudies-arrayexpress

Expression data for serum stimulation of human primary fibroblasts

Project description:We used microarrays to profile gene expression changes following growth factor stimulation of primary human fibroblasts. We serum starved (0.1% serum) fibroblasts for 48 hrs and restimulated with 10% serum for 0, 2, 4, 6 and 8 hrs. Total RNA was extracted from 2 independent biological replicas for each time point and hybridized to expression arrays.

2010-05-27 | E-GEOD-20641 | biostudies-arrayexpress

Large-scaled metabolic profiling of human dermal fibroblasts derived from pseudoxanthoma elasticum patients and healthy controls.

Project description:Mutations in the ABC transporter ABCC6 were recently identified as cause of Pseudoxanthoma elasticum (PXE), a rare genetic disorder characterized by progressive mineralization of elastic fibers. We used an untargeted metabolic approach to identify biochemical differences between human dermal fibroblasts from healthy controls and PXE patients in an attempt to find a link between ABCC6 deficiency, cellular metabolic alterations and disease pathogenesis. 358 compounds were identified by mass spectrometry covering lipids, amino acids, peptides, carbohydrates, nucleotides, vitamins and cofactors, xenobiotics and energy metabolites. We found substantial differences in glycerophospholipid composition, leucine dipeptides, and polypeptides as well as alterations in pantothenate and guanine metabolism to be significantly associated with PXE pathogenesis. These findings can be linked to extracellular matrix remodeling and increased oxidative stress, which reflect characteristic hallmarks of PXE. Our study could facilitate a better understanding of biochemical pathways involved in soft tissue mineralization.

| S-EPMC4181624 | biostudies-literature

Transcription profiling of human cancer-associated fibroblasts treated with dasatinib

Project description:Effect of Dasatinib on primary cancer-associated fibroblasts from lung cancer specimens.

| S-ECPF-MEXP-2546 | biostudies-other

Transcription profiling of human ischemic cardiomyopathy, idiopathic cardiomyopathy, and nonfailing controls

Project description: Not available

| S-DIXA-D-1166 | biostudies-other