Unknown,Transcriptomics

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Transcription profiling of blood from two human donors was incubated for timepoints up to 24 hours in the presence and absence of live meningococci

ABSTRACT: Blood from two donors was incubated for timepoints up to 24 hours in the presence and absence of live meningococci. The donors are labelled NP and SW. 'SWB' refers to blood that was incubated with meningococci; 'Unstim' refers to control blood incubated in the absence of meningococci. Duplicate arrays were prepared for the majority of timepoints ('a' and 'b'), except where the array of of poor quality and not used in the analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Janos Demeter 

PROVIDER: E-SMDB-2328 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

<h4>Background</h4>Myocardial failure has a central role in the complex pathophysiology of septic shock and contributes to organ failure and death. During the sepsis-induced inflammatory process, specific factors are released that depress myocardial contractile function. We aimed to identify these mediators of myocardial depression in meningococcal septic shock.<h4>Methods</h4>We combined gene-expression profiling with protein and cellular methods to identify a serum factor causing cardiac dysfu  ...[more]

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