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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of normal human kidney

ABSTRACT: This set of arrays was published in Molecular Biology of the Cell. The manuscript was released electronically on 12/01/2003 and the hard copy version in February 2004. The FT number indicates the kidney from which the component parts were dissected.

ORGANISM(S): Homo sapiens

SUBMITTER: Janos Demeter

PROVIDER: E-SMDB-2436 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression in the normal adult human kidney assessed by complementary DNA microarray.

Higgins John P T JP Wang Lingli L Kambham Neeraja N Montgomery Kelli K Mason Veronica V Vogelmann Stefanie U SU Lemley Kevin V KV Brown Patrick O PO Brooks James D JD van de Rijn Matt M

Molecular biology of the cell 20031202 2

The kidney is a highly specialized organ with a complex, stereotyped architecture and a great diversity of functions and cell types. Because the microscopic organization of the nephron, the functional unit of the kidney, has a consistent relationship to the macroscopic anatomy of the kidney, knowledge of the characteristic patterns of gene expression in different compartments of the kidney could provide insight into the functions and functional organization of the normal nephron. We studied gene ...[more]

PMID: 14657249

Similar Datasets

Gene expression in the normal adult human kidney

Project description:This set of arrays was published in Molecular Biology of the Cell. The manuscript was released electronically on 12/01/2003 and the hard copy version in February 2004. The FT number indicates the kidney from which the component parts were dissected. Abstract: The kidney is a highly specialized organ with a complex, stereotyped architecture and a great diversity of functions and cell types. Because the microscopic organization of the nephron, the functional unit of the kidney, has a consistent relationship to the macroscopic anatomy of the kidney, knowledge of the characteristic patterns of gene expression in different compartments of the kidney could provide insight into the functions and functional organization of the normal nephron. We studied gene expression in dissected renal lobes of five adult human kidneys using cDNA microarrays representing approximately 30,000 different human genes. Total RNA was isolated from sections of the inner and outer cortex, inner and outer medulla, papillary tips, and renal pelvis and from glomeruli isolated by sieving. The results revealed unique and highly distinctive patterns of gene expression for glomeruli, cortex, medulla, papillary tips, and pelvic samples. Immunohistochemical staining using selected antisera confirmed differential expression of several cognate proteins and provided histological localization of expression within the nephron. The distinctive patterns of gene expression in discrete portions of the kidney may serve as a resource for further understanding of renal physiology and the molecular and cellular organization of the nephron An all pairs experiment design type is where all labeled extracts are compared to every other labeled extract. Computed

2005-12-29 | E-GEOD-3931 | biostudies-arrayexpress

Gene expression in the normal adult human kidney

2005-12-30 | GSE3931 | GEO

Project description:Metagenome Microbial Mat 2003/2004

| PRJNA470588 | ENA

Queen conch (Strombus gigas) ovarian gene expression in the Florida Keys: offshore versus nearshore

Project description:Reproduction of queen conchs at nearshore sites in the Florida Keys is known to be impaired (Delgado et al. 2004). A recent microarray study of male queen conchs collected from the Florida Keys during the early part of the reproductive season (February, 2007) indicated that NS conchs show differences in expression of spermatogenesis-related and small GTPase signaling transcripts (Spade et al. 2010). The current study investigates gene expression in the ovary of female queen conchs from the same sampling effort in February, 2007.

2011-06-07 | GSE29756 | GEO

Queen conch (Strombus gigas) digestive gland gene expression in the Florida Keys: offshore versus nearshore

Project description:Reproduction of queen conchs at nearshore sites in the Florida Keys is known to be impaired (Delgado et al. 2004). A recent microarray study of male queen conchs collected from the Florida Keys during the early part of the reproductive season (February, 2007) indicated that NS conchs show differences in expression of spermatogenesis-related and small GTPase signaling transcripts (Spade et al. 2010). The current study investigates gene expression in the digestive gland, which is closely associated with ovary, of female queen conchs from the same sampling effort in February, 2007.

2011-06-07 | GSE29757 | GEO

BAC CGH array profiling using Phi29-amplified microdissected samples

Project description:Details of the experiment are available within the Nucleic Acid Research, 2004 manuscript "Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH", by Cardoso J. et al. Keywords: other

2004-10-23 | GSE1841 | GEO

Developing seeds of M955 low phytic acid barley 7 days after anthesis

Project description:Effect of the low phytic acid mutation on gene expression of developing seeds of M955, a low phytic acid barley genotype with >90% reduction in phytic acid in mature seeds. Expression analysis using the Barley1 GeneChip was performed on total RNA from developing seeds (7DAA) of M955 lpa and wt sib-selections. Sib-selections were from BC2 populations of M955 with Harrington as the recurrent parent. Material was grown in field trials in two years 2003 and 2004. In 2003 expression analysis was done from 2 lpa and 3 wt sib-selections, and in 2004 analysis was done from 2 lpa and 2 wt sib-selections. ****[PLEXdb(http://www.plexdb.org) has submitted this series at GEO on behalf of the original contributor, David Bowen. The equivalent experiment is BB22 at PLEXdb.]

2011-11-22 | GSE33395 | GEO

acute genes during CNS injury and their expression in cultured astrocytes

Project description:A robust set of CNS transcript changes was defined by comparing microarray data that describe the injury response of the rat retina [Vazquez-Chona et al., IOVS 2004; GSE1001], brain [Matzilevich et al., J Neurosci Res 2002; GSE1911], and spinal cord [Di Giovanni et al., Ann Neurol 2003; GDS63]. We determined the CNS injury genes that were expressed in cultured astrocytes from rat cortex [GSM34300] and from human optic nerve head [Yang et al., Physiol Genomics 2004; GDS532]. Keywords: other

2005-07-01 | GSE1928 | GEO

Peak Learning of Mass Spectrometry Imaging Data Using Artificial Neural Networks (Prostate tissue)

Project description:The human prostate tissue sample was analyzed by 2D MALDI FT ICR MSI. For detailed information we refer to the msiPL manuscript by Abdelmoula et al.

2021-06-20 | ST001857 | MetabolomicsWorkbench

Developing seeds of M955 low phytic acid barley 7 days after anthesis

2011-11-22 | E-GEOD-33395 | biostudies-arrayexpress

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