Comparative genomic hybridization of 5 hominid species, including humans

ABSTRACT: Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several hominoid lineages. Interspecies cDNA array-based comparative genomic hybridization was used to individually compare copy number variation for 39,711 cDNAs, representing 29,619 human genes, across five hominoid species, including human. We identified 1,005 genes, either as isolated genes or in clusters positionally biased toward rearrangement-prone genomic regions, that produced relative hybridization signals unique to one or more of the hominoid lineages. Measured as a function of

ORGANISM(S): Homo sapiens

SUBMITTER: Young Kim 

PROVIDER: E-SMDB-2855 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress