Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ali Salim
PROVIDER: E-SMDB-2999 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Salim Ali A Nacamuli Randall P RP Morgan Elise F EF Giaccia Amato J AJ Longaker Michael T MT
The Journal of biological chemistry 20040719 38
Vascular disruption following bony injury results in a hypoxic gradient within the wound microenvironment. Nevertheless, the effects of low oxygen tension on osteogenic precursors remain to be fully elucidated. In the present study, we investigated in vitro osteoblast and mesenchymal stem cell differentiation following exposure to 21% O(2) (ambient oxygen), 2% O(2) (hypoxia), and <0.02% O(2) (anoxia). Hypoxia had little effect on osteogenic differentiation. In contrast, short-term anoxic treatme ...[more]