Transcription profiling of Campylobacter jejuni stress survival and virulence-associated phenotypes

ABSTRACT: Campylobacter jejuni is a highly prevalent food-borne pathogen that causes diarrhoeal disease in humans. A natural zoonotic, it must overcome significant stresses both in vivo and during transmission despite the absence of several traditional stress response genes. Its ability to interact with and invade human intestinal epithelial cells closely correlates with virulence. A C. jejuni microarray-based screen revealed that several known virulence genes and several uncharacterized genes, including spoT, were rapidly upregulated during infection of human epithelial cells. spoT and its homologue relA have been shown in other bacteria to regulate the stringent response, an important stress response that to date had not been demonstrated for C. jejuni. We have found that C. jejuni mounts a string

ORGANISM(S): Campylobacter jejuni

SUBMITTER: Erin Gaynor 

PROVIDER: E-SMDB-3292 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress