Transcription profiling of adult acute myeloid leukemia associated with drug resistance

ABSTRACT: Acute myeloid leukemia (AML) patients are primarily resistant to induction chemotherapy in 20-50%. Previously it has been shown that resistance to the first cycle of induction chemotherapy is an independent prognostic factor. We investigated whether resistance to chemotherapy can be represented by gene-expression profiling, and which genes are associated with resistance. cDNA microarrays containing ~41.000 features were used to compare the gene-expression profile of AML blasts between 33 patients with good or poor response to induction chemotherapy. Data generated by cDNA-arrays were confirmed by quantitative RT-PCR. Using Significance Analysis of Microarrays, we identified a characteristic gene-expression profile which distinguished good- from poor-response AML samples. In hierarchical cl

ORGANISM(S): Homo sapiens

SUBMITTER: Doris Steinemann 

PROVIDER: E-SMDB-3491 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress