Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Janos Demeter
PROVIDER: E-SMDB-4028 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Li Tzu-Huey TH Zhao Hongjuan H Peng Yue Y Beliakoff Jason J Brooks James D JD Sun Zijie Z
Nucleic acids research 20070410 8
Although the vital role of the androgen receptor (AR) has been well demonstrated in primary prostate cancers, its role in the androgen-insensitive prostate cancers still remains unclear. Here, we used a small hairpin RNA approach to directly assess AR activity in prostate cancer cells. Reduction of AR expression in the two androgen-sensitive prostate cancer cell lines, LNCaP and LAPC4, significantly decreased AR-mediated transcription and cell growth. Intriguingly, in two androgen-insensitive pr ...[more]