Transcription profiling of thymocytes from Kruppel-like transcription factor (KLF)13 knock-out mice

ABSTRACT: Kruppel-like transcription factor (KLF)13, previously shown to regulate RANTES expression in vitro, is a member of the Kruppel- like family of transcription factors that controls many growth and developmental processes. To ascertain the function of KLF13 in vivo, Klf13-deficient mice were generated by gene targeting. As expected, activated T lymphocytes from Klf13-/- mice show decreased RANTES expression. However, these mice also exhibit enlarged thymi and spleens. TUNEL, as well as spontaneous and activation-induced death assays, demonstrated that prolonged survival of Klf13-/- thymocytes was due to decreased apoptosis. Microarray analysis suggests that protection from apoptosis-inducing stimuli in Klf13-/- thymocytes is due in part to increased expression of BCL-XL, a potent antiapoptoti

ORGANISM(S): Mus musculus

SUBMITTER: Janos Demeter 

PROVIDER: E-SMDB-4035 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress