Comparative genomic hybridization by array of human de novo actue myeloid leukemia (p-AML) samples and normal samples

ABSTRACT: Therapy-related acute myeloid leukemia (t-AML) is a severe complication of the cytotoxic therapy used for primary cancer treatment. The outcome of these patients is poor compared to people who develop de novo acute myeloid leukemia (p-AML). Chromosome abnormalities in t-AML are partly dependent on the induction agent. Partial or total losses of chromosome 5 and/or 7 are observed after therapy with alkylating agents. Balanced translocations, most of which involve 11q23 with MLL rearrangement, are found after treatment with the topoisomerase II inhibitor. Complex cases are also more frequent. The aim of this study was to compare t-AML to p-AML using high-resolution array CGH in order to identify gene-specific copy number abnormalities (CNA). Thirty t-AML versus thirty-six p-AML patient sampl

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Philippe DESSEN 

PROVIDER: E-TABM-1014 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress