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Oligonucleotide expression microarray data for analysis of Wilms tumor 1 gene (WT1) mutations in cytogenetically normal acute myeloid leukemia (AML) patient samples

ABSTRACT: Oligonucleotide expression microarray data used for expression signature associated with WT1 mutations in cytogenetically normal AML patient samples

ORGANISM(S): Homo sapiens

SUBMITTER: Guido Marcucci

PROVIDER: E-TABM-1020 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.

Becker Heiko H Marcucci Guido G Maharry Kati K Radmacher Michael D MD Mrózek Krzysztof K Margeson Dean D Whitman Susan P SP Paschka Peter P Holland Kelsi B KB Schwind Sebastian S Wu Yue-Zhong YZ Powell Bayard L BL Carter Thomas H TH Kolitz Jonathan E JE Wetzler Meir M Carroll Andrew J AJ Baer Maria R MR Moore Joseph O JO Caligiuri Michael A MA Larson Richard A RA Bloomfield Clara D CD

Blood 20100504 5

We previously reported the adverse prognostic impact of Wilms tumor 1 gene (WT1) mutations in younger adult cytogenetically normal acute myeloid leukemia (CN-AML). Here, we investigated 243 older (> or = 60 years) primary CN-AML patients. WT1 mutated (WT1mut) patients (7%) had FLT3-ITD more frequently (P < .001), lower hemoglobin (P = .01), higher white blood cell count (P = .03) and percentage blood blasts (P = .03), and a shorter overall survival (P = .08) than WT1 wild-type (WT1wt) patients. ...[more]

PMID: 20442368

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