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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Saccharomyces cerevisiae knock-outs of non-essential chromatin modifiers

ABSTRACT: Non-essential knockouts of chromatin modifiers have been investigated by expression profiling.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Patrick Kemmeren

PROVIDER: E-TABM-1074 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator.

Gonzalez Deyarina D Hamidi Nurul N Del Sol Ricardo R Benschop Joris J JJ Nancy Thomas T Li Chao C Francis Lewis L Tzouros Manuel M Krijgsveld Jeroen J Holstege Frank C P FC Conlan R Steven RS

Proceedings of the National Academy of Sciences of the United States of America 20140203 7

Mediator, an evolutionary conserved large multisubunit protein complex with a central role in regulating RNA polymerase II-transcribed genes, serves as a molecular switchboard at the interface between DNA binding transcription factors and the general transcription machinery. Mediator subunits include the Cdk8 module, which has both positive and negative effects on activator-dependent transcription through the activity of the cyclin-dependent kinase Cdk8, and the tail module, which is required fo ...[more]

PMID: 24550274

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