Transcriptomic Analysis of Embryonic Mammary Cells

ABSTRACT: The mammary primordium represents the earliest evidence of commitment to the mammary lineage. The primordium forms via inductive tissue interactions between its constitutive tissues, the mesenchyme and epithelium. Here, we describe an analysis of the transcriptome of the mammary bud epithelium and its associated mesenchyme, two distinct cellular compartments that comprise the mammary primordium. Using network analysis, we found candidate mediators of mammary cell fate, differentiation and progenitor cell function that signal from mammary lineage inception during embryogenesis through postnatal development. Genetic features of mammary primordial cells overlapping with human breast progenitor cells identified potential regulators of key progenitor cell functions conserved across species. The

ORGANISM(S): Mus musculus

SUBMITTER: Alan Mackay 

PROVIDER: E-TABM-1099 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress