A yeast-based assay identifies drugs active against human mitochondrial disorders

ABSTRACT: Transcriptome profile of S. cerevisiae strain MC6 (deletion mutant for the ATP synthase assembly factor FMC1, used as a yeast model of mitochondrial disease) grown at 35C in rich galactose media supplemented with either 1.25uM chlorhexidine (a drug identified in a yeast-based screen with potential therapeutic effects) or DMSO as a control. The isogenic wild-type strain (MC1) was included as a control. Strains originate from http://www.ncbi.nlm.nih.gov/pubmed/11096112 and the arrays used were yeast tiling microarrays from Affymetrix.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Charles Girardot 

PROVIDER: E-TABM-1176 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress