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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of MYCN non-amplified stage 4S neuroblastomas

ABSTRACT: Molecular phenotype of MYCN non-amplified stage 4S neuroblastoma

ORGANISM(S): Homo sapiens

SUBMITTER: Hugues Ripoche

PROVIDER: E-TABM-119 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MYCN-non-amplified metastatic neuroblastoma with good prognosis and spontaneous regression: a molecular portrait of stage 4S.

Bénard Jean J Raguénez Gilda G Kauffmann Audrey A Valent Alexander A Ripoche Hugues H Joulin Virginie V Job Bastien B Danglot Gisèle G Cantais Sabrina S Robert Thomas T Terrier-Lacombe Marie-José MJ Chassevent Agnès A Koscielny Serge S Fischer Matthias M Berthold Frank F Lipinski Marc M Tursz Thomas T Dessen Philippe P Lazar Vladimir V Valteau-Couanet Dominique D

Molecular oncology 20080723 3

Stage 4 neuroblastoma (NB) are heterogeneous regarding their clinical presentations and behavior. Indeed infants (stage 4S and non-stage 4S of age <365days at diagnosis) show regression contrasting with progression in children (>365days). Our study aimed at: (i) identifying age-based genomic and gene expression profiles of stage 4 NB supporting this clinical stratification; and (ii) finding a stage 4S NB signature. Differential genome and transcriptome analyses of a learning set of MYCN-non ampl ...[more]

PMID: 19383347

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