Gene expression signature associated with ASXL1 mutations in cytogenetically normal acute myeloid leukemia (CN-AML)

ABSTRACT: We studied gene expression profiles from 65 patients with CN-AML, who all had wild-type NPM1 and no FLT3-ITD. We identified an ASXL1 mutation-associated gene expression signature by comparing 26 ASXL1-mutated and 39 ASXL1-wild type patients. Only NPM1 wild type/FLT3-ITD-negative patients were included in this analysis to avoid potential confounding due to the effects of these two mutations on gene expression.

ORGANISM(S): Homo sapiens

SUBMITTER: Guido Marcucci 

PROVIDER: E-TABM-1208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress