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Neural embryonic stem cell (ESTn) test dose-responses of six compounds.

ABSTRACT: Effects of six compounds on stem cell neural development.

ORGANISM(S): Mus musculus

SUBMITTER: Jeroen Pennings

PROVIDER: E-TABM-1216 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn).

Theunissen P T PT Robinson J F JF Pennings J L A JL van Herwijnen M H MH Kleinjans J C S JC Piersma A H AH

Toxicology and applied pharmacology 20120523 3

Alternative assays for developmental toxicity testing are needed to reduce animal use in regulatory toxicology. The in vitro murine neural embryonic stem cell test (ESTn) was designed as an alternative for neurodevelopmental toxicity testing. The integration of toxicogenomic-based approaches may further increase predictivity as well as provide insight into underlying mechanisms of developmental toxicity. In the present study, we investigated concentration-dependent effects of six mechanistically ...[more]

PMID: 22634333

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